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The solubility characteristics of β-casein are analyzed by techniques of differential scanning calorimetry, Fourier transform infrared spectroscopy, and microcalorimetry. The results show that β-casein exhibits a glass transition at (Tg) = 55 °C. By differential scanning calorimetry, β-casein incubated for 5 days at 55 °C in the presence of 10 mM HCl or 6 M urea forms an amorphous glass. The glass is characterized by a high value of enthalpy of transition, large heat capacity change, and the absence of a peak associated with β-casein secondary structure. In the presence of Ca(2+) ions, the β-casein glass exhibits a higher Tg compared to that obtained in the absence of Ca(2+) ions. Fourier transform infrared spectroscopy of an equimolar mixture of β-casein and α-casein demonstrates that β-casein forms a glass-like complex with α-casein through a regular Ca(2+)-mediated hydrogen bond network. The amorphous glass of β-casein formed at 55 °C in the presence of Ca(2+) ions is characterized by a high glass transition enthalpy and an enthalpy of transition higher than that of the amorphous solution, a large heat capacity change during the glass transition, and
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Stabilization planning for post-hospital care is prone to errors and provides inadequate feedback to assess safety. A conceptual framework is proposed to review contemporary research on this topic and to help systemwide, continuous improvement. We conducted a review of the research literature for key papers and used this information to develop the framework. We identified all published research on the subject of post-hospital care planning. A review of the data identified frameworks of concepts, key findings, and a proposed conceptual framework that combines these concepts. Three key concepts identified in the literature are necessary and sufficient conditions for successful stabilization planning: medications, vital signs, and other measures. The concept of patient follow-up is similarly inadequate but all-encompassing. Two other concepts are the structures that facilitate stabilization planning: teams and information systems. The proposed conceptual framework was then refined to include complex relationships. The three key concepts are important in post-hospital stabilization and require facilities to have the necessary structures. Healthcare professionals are particularly important to the stability process, particularly in the case of